Designing and Developing a Web-based Enterprise Information System

Client Situation

With the advent of new HIV/AIDS-related discoveries, the Division of AIDS (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID) saw a rapid and dramatic increase in the scope, magnitude, and complexity of its clinical research agenda. Consequently, the DAIDS needed an improved enterprise system that would support its global operations, improve data sharing and collaboration, and reduce administrative costs. When we took on this project, the number of DAIDS active clinical studies had nearly doubled, with more than 300 new international clinical performance sites in more than 30 countries.

The Digital Infuzion Solution

Digital Infuzion and Capital Technology Information Services (CTIS) designed and developed a scalable, robust, web-based enterprise information system—called the DAIDS Enterprise System (DAIDS-ES)—which now provides simple, unified access to multiple sources of data generated by DAIDS-sponsored clinical trials worldwide. Beginning in June 2002, our software developers and systems engineers analyzed and developed DAIDS’ business processes to overcome existing barriers to efficient data entry, access, dissemination, and exchange. Early versions of major system components were developed and delivered successfully in August 2006. The system now supports the full life cycle of critical enterprise activities and objectives, from protocol management and clinical site monitoring to wireless database queries and adverse experience reporting.


  • Preserve essential and institutional knowledge.
  • Allow DAIDS staff to spend more time using key information, rather than chasing it down.
  • Enhance information exchange and collaboration across DAIDS and its programs.
  • Bring DAIDS infrastructure and office automation into the 21st century.
  • Reduce infrastructure and development costs.
  • Streamline compliance with Federal regulations and data standards.
  • Simplify protocol management and abstraction.
  • Provide flexible access to centralized contact information.
  • Give support for wireless information access and dissemination.
  • Improve support for clinical site monitoring.
  • Provide rapid, secure, accurate adverse event reporting.